Current Issue : January - March Volume : 2021 Issue Number : 1 Articles : 5 Articles
Vascular endothelial growth factor (VEGF) expression increased significantly in the\npathogenesis of age-related macular degeneration, which induced the formation of pathological blood\nvessels. Dexamethasone is an exogenous anti-angiogenic drug while bevacizumab is an endogenous\nanti-angiogenic drug. They both have been widely used in ophthalmology. However, independent\nadministration is not enough to completely block the development of choroidal neovascularization\n(CNV), and the number of eyes vitreous injections is limited. Reasonable combination of drugs may\nproduce significantly better therapeutic effect than single drug treatment. The cyclic RGD (cRGD)\npeptide has a particularly high affinity with retinal pigment epithelial cells, where VEGF secretes from.\nIn this study, we prepared nanoparticles of bevacizumab and dexamethasone with cRGD peptide\nas the target (aBev/cRGD-DPPNs). The particle size of the aBev/cRGD-DPPNs was......................
Paclitaxel (PTX) and anastrozole (ANA) have been frequently applied in breast cancer\ntreatment. PTX is well-known for its anti-proliferative effect meanwhile ANA has just been discovered\nto act as an estrogen receptor ........................
The aim of the study was to mask the bitter taste of fexofenadine HCl using Eudragit E100 and prepared the chewable tablet. The taste masked granules of fexofenadine HCl were prepared by wet granulation method using pH sensitive, cationic copolymer eudragit E100 and pre-gelatinized starch as disintegrant and prepared into chewable tablet. Central composite design (CCD) was applied as an optimization technique. As eudragit E100 is soluble at pH below 5, the dissolution was assessed using USP dissolution apparatus-II in 0.001 N HCl (pH 1.2) simulated gastric fluid was chosen as the dissolution medium. FTIR and DSC studies indicated that drug and excipients were compatible with each other. The key attributes i.e. hardness, dissolution and disintegration test was performed successfully. The optimized batch FH1 passes all the pre-compression and post-compression parameters and it was given as best by CCD. Taste-masking evaluation was done successfully. Disintegration time was obtained 16 min. The % drug released was found to be 99.40% within 60 min. It was concluded that the aim of taste masking of fexofenadine HCl using eudragit E100 and formulated into chewable tablet by wet granulation method was successfully achieved....
In this work we describe the relationship between surface modification of\nhexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal\nanti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with\n3-aminopropyl, phenyl and cyclohexyl groups by grafting method. Naproxen was adsorbed into pores\nof the prepared MPS from ethanol solution using a solvent evaporation method. The release of the\ndrug was performed in buffer medium at pH 2 and physiological solution at pH 7.4. Parent MPSs as\nwell as naproxen loaded MPSs were characterized using physicochemical techniques such as nitrogen\nadsorption/desorption, thermogravimetric analysis (TG), Zeta potential analysis, Fourier transform\ninfrared spectroscopy (FT-IR), and elemental analysis. The amount of naproxen released from the\nMPSs into the medium was determined by high-performance liquid chromatography (HPLC). It was\nshown that the adsorption and desorption characteristics of naproxen are dependent on the pH of the\nsolution and the surface functionalization of the host...
Risperidone (RSP) is an atypical antipsychotic drug widely used to treat schizophrenia\nand bipolar disorder. Nanoparticles (NPs) are being developed as in vivo targeted drug delivery\nsystems, which cross the blood-brain barrier and improve pharmacokinetics and drug effectiveness.\nHere, biodegradable proteinoids were synthesized by thermal step-growth polymerization from the\namino acids l-glutamic acid, l-phenylalanine and l-histidine and poly (l-lactic acid). Proteinoid NPs\ncontaining RSP were then formed by self-assembly.....................................
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